Abstract
BackgroundCandidemia is a common cause of nosocomial bloodstream infections, resulting in high morbidity and mortality. This study was conducted to describe the epidemiology, species distribution, antifungal susceptibility patterns and outcomes of candidemia in a large regional tertiary referral hospital.MethodsA retrospective surveillance study of patients with candidemia was conducted at Singapore General Hospital between July 2012 and December 2015. In addition, incidence densities and species distribution of candidemia episodes were analysed from 2008 to 2015.ResultsIn the period of 2012 to 2015, 261 candidemia episodes were identified. The overall incidence was 0.14/1000 inpatient-days. C. glabrata (31.4%), C. tropicalis (29.9%), and C. albicans (23.8%) were most commonly isolated. The incidence of C. glabrata significantly increased from 2008 to 2015 (Coefficient 0.004, confidence interval 0–0.007, p = 0.04). Fluconazole resistance was detected primarily in C. tropicalis (16.7%) and C. glabrata (7.2%). fks mutations were identified in one C. albicans and one C. tropicalis. Candidemia episodes caused by C. tropicalis were more commonly encountered in patients with haematological malignancies (p = 0.01), neutropenia (p < 0.001) and higher SAPS II scores (p = 0.02), while prior exposure to echinocandins was associated with isolation of C. parapsilosis (p = 0.001). Echinocandins (73.3%) were most commonly prescribed as initial treatment. The median (range) time to initial treatment was 1 (0–9) days. The 30-day in-hospital mortality rate was 49.8%. High SAPS II score (Odds ratio, OR 1.08; 95% confidence interval, CI 1.05–1.11) and renal replacement therapy (OR 5.54; CI 2.80–10.97) were independent predictors of mortality, while drain placement (OR 0.44; CI 0.19–0.99) was protective.ConclusionsDecreasing azole susceptibilities to C. tropicalis and the emergence of echinocandin resistance suggest that susceptibility patterns may no longer be sufficiently predicted by speciation in our institution. Candidemia is associated with poor outcomes. Strategies optimising antifungal therapy, especially in the critically-ill population, should be explored.
Highlights
Candidemia is a common cause of nosocomial bloodstream infections, resulting in high morbidity and mortality
Analysing the incidence densities from 2008 to 2015, we found no significant change in the incidence density of candidemia [Coefficient 0.00009, confidence interval (CI) - 0.007–0.007, p = 0.98]
We report here a comprehensive epidemiological study of candidemia conducted at a large tertiary regional referral centre, which included the clinical characteristics, antifungal treatment, species distribution, antifungal susceptibilities and outcomes of candidemia
Summary
Candidemia is a common cause of nosocomial bloodstream infections, resulting in high morbidity and mortality. This study was conducted to describe the epidemiology, species distribution, antifungal susceptibility patterns and outcomes of candidemia in a large regional tertiary referral hospital. Candidemia has a profound impact on patient outcomes and the burden has increased significantly over the years. Increasing reports of antifungal resistance, even in newer agents such as the echinocandins, further escalate the complexity in the management of candidemia [7]. The variable epidemiology of candidemia, contributed by the geographical and temporal variations in incidence and species distribution [4, 8,9,10], underscores the continuing need for local surveillance of Candida species distribution and susceptibility patterns
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