Candidate Genes of Regulation of Skeletal Muscle Energy Metabolism in Athletes.

Mustafa Al-Zamil,German V. Medvedev,Vera V. Trefilova,Natalia A. Shnayder,Marina M. Petrova,Evgeny V. Bykov,Margarita A. Zhogina,Olga V. Balberova,Polina S. Goncharova,Kirill V. Petrov

doi:10.3390/genes12111682

Abstract

All biological processes associated with high sports performance, including energy metabolism, are influenced by genetics. DNA sequence variations in such genes, single nucleotide variants (SNVs), could confer genetic advantages that can be exploited to achieve optimal athletic performance. Ignorance of these features can create genetic “barriers” that prevent professional athletes from pursuing a career in sports. Predictive Genomic DNA Profiling reveals single nucleotide variations (SNV) that may be associated with better suitability for endurance, strength and speed sports. (1) Background: To conduct a research on candidate genes associated with regulation of skeletal muscle energy metabolism among athletes. (2) Methods: We have searched for articles in SCOPUS, Web of Science, Google Scholar, Clinical keys, PubMed, e-LIBRARY databases for the period of 2010–2020 using keywords and keywords combinations; (4) Conclusions: Identification of genetic markers associated with the regulation of energy metabolism in skeletal muscles can help sports physicians and coaches develop personalized strategies for selecting children, teenagers and young adults for endurance, strength and speed sports (such as jogging, middle or long distance runs). However, the multifactorial aspect of sport performances, including impact of genetics, epigenetics, environment (training and etc.), is important for personalized strategies for selecting of athletes. This approach could improve sports performance and reduce the risk of sports injuries to the musculoskeletal system.

Highlights

The proportion of competitive period in the annual training cycle in cyclic sports has significantly increased [1]
Objective of the thematic review—to conduct a research on candidate genes associated with regulation of skeletal muscle energy metabolism in athletes
According to our analysis of studies of candidate genes encoding structural proteins and enzymes involved in the regulation of energy metabolism in skeletal muscles, the researchers’ interest in sports genetics has been increasing in recent years

Summary

Introduction

The proportion of competitive period in the annual training cycle in cyclic sports (such as running disciplines of athletics) has significantly increased [1]. This makes high demands on the physiological and biochemical aspects of training athletes on the first place. (such as running disciplines of athletics) has significantly increased [1] As sports will be determined, firstly, by the availability of adenosine triphosphate (ATP) as the the main substrate of energy supply and, secondly, by the number of skeletal muscle momain substrate of energy supply and, secondly, by the number of skeletal muscle motor tor units involved.

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Discussion

Conclusion