Candidate EPA, NIOSH method for determining carbon disulfide in air with capillary gas chromatography by orthogonal design

Abstract

This paper describes a candidate NIOSH EPA method for the determination of carbon disulfide in the air of workplaces with capillary gas chromatography using an orthogonal design. This method is designed to replace the packed column of the NIOSH method with a capillary column. The first part of this work concerned the setup of the method, particularly the choice of chromatographic parameters and finding their main favorable working ranges. The second part, using the statistical method orthogonal design, focused on optimizing the GC conditions, which were: column temperature, Tc = 90°C; injector temperature, Ti = 140°C; U section detector temperature, FPDU = 160°C; L section detector temperature, FPDL = 210°C; flow rate of carrier gas, Fc = 20 cm/s; split ratio = 1/70; and injection volume = 1 µL. The quality control test showed that the coefficient of intra-day variation (CV) was 2.21%. A good logarithm linear correlation between the standard solutions and their peak areas was obtained. In general, the method reported here seems a valid candidate for a NIOSH EPA method due to its high precision and accuracy. Copyright © 1999 John Wiley & Sons, Ltd.