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Abstract
Abstract Zinc is one of the most important trace elements and deficiency can lead to significant clinical complications. Microbial transformation is one of the most important methods used to supplement organic zinc and there may be some naturally occurring microorganisms that have both higher zinc tolerances and transformation capabilities. In this study, microorganisms which displayed such characteristics were widely screened, and a strain designated T-A was found. Morphological and molecular determination demonstrated that T-A is closely related to Candida tropicalis with 87% of 18S rDNA homology, with a G+C content measured by RP-HPLC of 88.42%. Candida tropicalis sp. T-A strains were shown to grow and transform zinc best at pH5 in medium with a zinc ion concentration of 8000 μg/mL at 28 °C for 121 hours. Our results showed C. tropicalis sp. T-A’s zinc content was 19.153 mg/g dry weight, with a relative bioavailability in rats of 173% when compared with traditional zinc supplements. Our study suggests that C. tropicalis sp. T-A could be exploited for use as a potential zinc supplement.
Highlights
Zinc(Zn) is one of the most essential and indispensable trace elements in cells (Chasapis et al, 2012)
The growth of B and T cells is adversely affected by zinc deficiency (Prasad, 2014)-which shows that appropriate zinc nutrition is important for human health (Hess et al, 2009)
The sequence obtained from the PCR of C. tropicalis sp
Summary
Zinc(Zn) is one of the most essential and indispensable trace elements in cells (Chasapis et al, 2012). It plays an important role in numerous enzyme systems and is involved in multiple biological pathways such as enzymatic catalysis, redox regulation, cellular signal transduction, the immune system and neurons (Zhang et al, 2014). It was believed that zinc deficiency in humans could lead to significant clinical disorders (Prasad, 2013), such as growth retardation, bullous pustular dermatitis, emotional disorder and cell mediated 54 immune dysfunctions (Prasad, 2008). Some studies have shown that zinc supplementation can reduce the incidence and duration of infectious diseases such as Staphylococcus aureus mediated pneumonia and Escherichia coli induced urinary tract infections (Prasad, 2008)
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