Candida spp Complications in Acute Myeloid Leukemia Patients in Erbil City

Payman A.Hamsaeed,Amera M Muhammad

doi:10.32441/kjps.02.02.p4

Payman A.Hamsaeed, Amera M Muhammad

Open Access

https://doi.org/10.32441/kjps.02.02.p4

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Abstract

This study has been carried out in Erbil City -Iraq, 30 patients were diagnosis by flow cytometry as AML which they were admitted to Nanakaly Hospital for Blood Disease and submitted to chemotherapy. Number of adults/children 22 (73.3%) / 8 (26.7%), female / male 13 (43.3%) / 17(56.7%). Only 20 (66.7%) patients were smoker. The highest number was subtyping M4 10 (33.3%) patients, followed by M1 7(23.3%), M3 6(20%), M2 were 3(10%) patients. M5 and M6 were 2 (6.7%). Ten candida spp isolates before induction phase chemotherapy show 9(90%) C.albicans, 1(10%) C. lusitaniae, and from 32 isolates after induction phase chemotherapy, 17(53.1%) C.albicans, 7(21.9%) C. lusitaniae, and 8(25%) C.famata. According to the site of infection, before starting chemotherapy 8(88.9%) C. albicans isolates were in the oral cavity and 1(11.1%) on the skin, while C. lusitaniae was 1 (100%) in oral cavity only. While after chemotherapy 12(70.6%) C.albicans in the oral cavity and 5(29.4%) on the skin, C. lusitaniae was 2 (28.6%) in the oral cavity and 5(71.4%) on the skin, while all C. famata was 8 (100%) on the skin The immunophenotype shows that the number and percentage of patients which the myeloid cells expressed cyMPO was 27(90) with mean percentage of positivity 59.38, while all patients expressed CD33 and CD13 on their blast cell 30(100) with a mean percentage of positivity 59.81 and 30.83 respectively.

Highlights

According to the site of infection, before starting chemotherapy 8(88.9%) C. albicans isolates were in the oral cavity and 1(11.1%) on the skin, while C. lusitaniae was 1 (100%) in oral cavity only
Blood cancer or leukemia is a type of blood or bone marrow (BM) cancer characterized by an abnormal increase of cells called "blasts" [1]
A- Patients This study included 30 newly diagnosed blood cancer patients type acute myeloid leukemia (AML) before treatment and after the first induction phase chemotherapy, they admitted to the" Nanacally Hospital for Blood Disease" in Erbil province A questionnaire form was provided to each patient which included age, sex, family degree, education level, smoking, residence

Summary

Introduction

Blood cancer or leukemia is a type of blood or bone marrow (BM) cancer characterized by an abnormal increase of cells called "blasts" [1]. Infectious complications Infections are an important cause of morbidity and mortality in leukemia patients, which are at high risk of infection, likely related to the intensity of their induction phase chemotherapy resulting in repeated episodes of prolonged and profound. Nosocomial candidemia occurs predominately in patients who have hematological malignancies and/or have undergone stem cell transplantation and is associated with a high mortality rate [9]. There has been a marked increase in the number of recognized cases of candidemia due to this organism in the last two decades, bone marrow transplantation and high dose cytoreductive chemotherapy have both been identified as risk factors for infections with this organism [12]. Candida Famata is a hemiascomycetous yeast commonly found in natural substrates and in cheese [13] It has been described in human infections [14][15]. C. famata has been reported in the patient undergoing chemotherapy for Hodgkin's disease and caused bloodstream infections [16][17]

Material and Methods

Results and Discussion

Conclusions