Candida guilliermondii grows on rare pentoses – implications for production of pure xylitol

Abstract

Feeding sucrose at 20 g l−1 on day 16 gave maximum paclitaxel production at 10 mg l−1 when Taxus chinensis in 5 l bioreactors. Paclitaxel accumulation was doubled by the cultivation of cells initially with dissolved O2 tension at 60% for 20 days followed by being at 20% for another 12 days in the bioreactor. Combination of these two strategies gave maximum paclitaxel production of 19 mg l−1 after 32 days.