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Abstract
Candida auris has emerged globally as a multidrug-resistant (MDR) medical care-associated fungal pathogen. Recent reports have demonstrated that C. auris usually expresses fewer virulence factors than does Candida albicans. However, the tendency of C. auris transmission within and between healthcare facilities is unique among Candida spp. and is possibly promoted by virulence and pathogenicity factors that facilitate skin colonization and environmental persistence. To understand the ability of this yeast to cause disease, we herein discuss several virulence and pathogenicity aspects of C. auris.
Highlights
Luana Rossato and Arnaldo Lopes Colombo*Special Mycology Laboratory, Universidade Federal de São Paulo, São Paulo, Brazil
Candida auris is an emerging multidrug-resistant (MDR) yeast pathogen that causes healthcareassociated invasive infections
When solid-phase cytometry was used to assess individual cells for viability for longer periods of time, the results indicated that the cells entered into a viable non-culturable state, and more viable C. auris than C. parapsilosis cells were detected at all time points (Welsh et al, 2017).Overall, the adherence of C. auris to medical devices may play a role in the development of catheter-related fungemia
Summary
Special Mycology Laboratory, Universidade Federal de São Paulo, São Paulo, Brazil. Edited by: Sascha Brunke, Leibniz Institute for Natural Product Research and Infection Biology, Germany. Reviewed by: Darius Armstrong-James, Imperial College London, United Kingdom Arianna Tavanti, University of Pisa, Italy. Specialty section: This article was submitted to Infectious Diseases, a section of the journal Frontiers in Microbiology. Candida auris has emerged globally as a multidrug-resistant (MDR) medical careassociated fungal pathogen. Recent reports have demonstrated that C. auris usually expresses fewer virulence factors than does Candida albicans. The tendency of C. auris transmission within and between healthcare facilities is unique among Candida spp. and is possibly promoted by virulence and pathogenicity factors that facilitate skin colonization and environmental persistence. To understand the ability of this yeast to cause disease, we discuss several virulence and pathogenicity aspects of C. auris
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