Abstract
The Lipolase-catalyzed ring opening of racemic 4-benzyl- 3 and 4-phenylethyl-2-azetidinone 4 was performed with 0.5equiv of H2O in diisopropyl ether at 45°C. The resulting (S)-β-amino acid 5 or 6 (ee⩾87%) and (R)-β-lactam 7 or 8 (ee>99%) enantiomers could easily be separated. The ring opening of enantiomeric β-lactams with 18% aqueous HCl afforded the corresponding enantiopure β-amino acid hydrochlorides 9 and 10 (ee>99%).
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