Abstract
Precipitins against mannan and less frequently against protein antigens of C. albicans Group A are common in asthma and especially in asthmatic patients with pulmonary eosinophilia. The mannan A precipitins are associated with Arthus, Type III, skin test reactions to mannan A. Inhalation tests, particularly with the culture filtrate, containing both mannan A and protein antigens, provoked systemic reactions coming on after 4 to 8 hours and immediate and late asthmatic reactions. Precipitins to C. albicans are present in most of the patients with asthma and pulmonary eosinophilia in whom precipitins to A. fumigatus, the commonest cause in the United Kingdom, are absent. Precipitin-mediated reactions to C. albicans may be clinically relevant in these cases. The mannan antigens are potently antigenic, a single skin test resulting in the appearance of precipitins in all subjects, in an increase in the size of the Type III skin test reactions, and in the number of patients giving such reactions.
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