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Abstract
Background: The pharmacological response and the therapeutic efficacy of a drug depends on the interactions with plasma proteins. Methodology: The interaction of bovine serum albumin (BSA) with themetal complexes of antihypertensive drugs, Zn(II)/sartan complexes (candesartan, valsartan andlosartan), was investigated using fluorescence quenching determinations at different temperatures. Results: The binding studies of the compounds with BSA showedstatic quenching and moderate binding with calculated constants in the range of 104-106M-1, indicating potent serum distribution via albumins. In all cases, negative values of free energy are indicative of spontaneous processes and the stabilization ofBSA/compound complexesthrough hydrogen bonding and van der Waals forces. The results for the sartans agree with thereported pharmacokinetics studies. Conclusion: It has been determined that the three sartans and the Zn complexes could be transported and distributed by albumin.
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