Abstract
Species and strains of animals differ in their tendency to develop tumors spontaneously and also in the prevalent tissues and cell types involved in this development We have found that a γ source of continuous radiation (cobalt 60 wires) implanted in young adult rodents and capable of inducing cancers of the types expected in this species will also produce cancers which rarely develop spontaneously. These are epidermoid carcinoma of the esophagus and lung and also osteogenic; sarcoma. Radiation carcinogenesis tends to override expected differences in susceptibility of species and strains. The rat appears highly susceptible to lung cancer, the mouse and hamster only slightly susceptible to osteogenic sarcoma. There appear to be optimal dose and dose-rate ranges for carcinogenesis but these may be obscured by biological variations.
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