Abstract
Cancer is not a single cell disease and its existence and behavior are constantly modulated by the host. Cancer gene expression and genetics are also highly dynamic and are regulated epigenetically by the host. In this chapter, we describe the molecular pathways leading to an unusual property of cancer cells: the ability to mimic the host microenvironment, and, in particular, the characteristics of osteomimicry and vasculogenic mimicry. We also discuss the importance of host inflammatory and stem cells, which contribute to the growth and survival of cancer cells. By understanding the salient features of cancer-host interaction, novel therapeutics may be developed to target both cancer and host in the treatment of lethal prostate cancer metastases.
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