Cancer-associated retinopathy in a patient with synchronous fallopian tubal and uterine corpus cancers

Abstract

Background: Cancer-associated retinopathy (CAR) is a paraneoplastic syndrome that significantly diminishes the quality of life of patients. Case Report: A 53-year-old woman with a history of glaucoma, cataract, and cerebral infarction was diagnosed with synchronous FIGO Stage IVB fallopian tubal cancer and Stage IA uterine corpus cancer. She complained of acute low vision and ring scotoma during the examination. Although her visual acuity was 25/20 in both eyes, and neither fundoscopy nor brain CT showed any abnormalities, electroretinography recorded no responses. Anti-recoverin antibodies were detected in her serum, and both fallopian tubal, and endometrial malignant cells expressed recoverin. These malignant tumours caused CAR. Although surgical debulking and chemotherapy reduced the size of the tumours, her low vision progressively worsened and anti-recoverin antibodies were still detected in her serum. Conclusion: The authors treated a rare case of CAR with synchronous fallopian tubal and endometrial cancer. This rare paraneoplastic syndrome should be considered during the differential diagnosis of ophthalmological symptoms in patients with malignant disease, as well as in the gynaecological field.