Abstract
Trophic properties of hematopoietic stem cells can influence the malignant growth alternatively to immune control. The annual growth of the body mass by age in adult populations of welfare countries used as the most common criterion of metabolic and proliferative tissue activity, and these data compared with death’ rate for malignant and somatic diseases in different age-groups of the same countries. The rate of physiologic involution of different cell populations in the lymphoid lineage by age also involved in correlations between the above parameters. A decrease in death rate for cancer and increase it’s for non-malignant diseases found in 60+ populations, which have the lowest physiological temp of renewal of lymphocytes number and mass of the body. The lack of both the thymus gland volume and proliferative activity of naive lymphocytes reduces physiological body mass renewal as well as the cancer death rate but enhances somatic death rate, opposing to anticancer immunity at large. A protumor character of the lymphopoietic system’s relation with malignancy seems more realistic than defending one.
Highlights
Though cancer-immune model has reached types of immune cells, types of cytokines, and 107 interaction links nowadays, the complexity of the model considers underestimated yet [1] [2], partly because the practical input of immuno-oncology is scanty
We investigated more carefully whether the features of lymphopoiesis decline monotonously by age in adults, or accelerate the negative rate at some critical age point, like a body mass growth
The decrease in the rate of cancer death after 60 natural age (Figure 3) would be unexplainable if the activation of cancer after BM transplantation were due to the weakening of immune defense, as it is usually explained
Summary
Though cancer-immune model has reached types of immune cells, types of cytokines, and 107 interaction links nowadays, the complexity of the model considers underestimated yet [1] [2], partly because the practical input of immuno-oncology is scanty. The changes in mean body weight (BW) are the simplest and most reliable parameter of the current metabolic energy’ state of an integrative renewing tissue in organism [13] [14] In the review, we compared together with the body weight, the cancer death rate, the death rate for non-malignant diseases, and lymphopoiesis by age and sex for human populations of countries with well socio-economy conditions, using complete and modern databases to provide most general conclusions for starting. Each part of the curve described by the exponential equation: S = Aeλt, where S is the current value, t is elapsed time in years, A is the initial value at t = 0, and λ is the constant exponential rate of changes per year for the given period It (λ) can be positive (+) or negative (¬). The p-value for R ± mR calculated according to the equation for Student’s t-test [15]:
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