Abstract
Irreversible electroporation (IRE) is a kind of non-thermal tumor treatment strategy. Based on this, Nanoknife emerged, which is approved by FDA in 2011. From then on, clinical application of nanosecond electrical pulsed have showed an explosive growth. At the cell level, the biophysical mechanism of nonthermal irreversible electroporation of electrical pulsed was studied. At the animal level, it has studied the safety of irreversible electroporation and preclinical animal experiments, also the clinical application of irreversible electroporation. We reviewed Animal studies of IRE and Clinical application of IRE. Also traditional medical imaging methods such as CT, magnetic resonance imaging (MRI) and ultra-sound imaging can be used in the IRE therapy. The evidences can prove the beneficial effects and safety of IRE in tumor treatment and verify the potential of IRE in clinical treatment to some extent. However, larger clinical trials are still needed to confirm these conclusions. Hopefully, as we go deeper into IRE, we get a more thorough understanding of it and the application will appear in various fields.
Highlights
Nanosecond pulse electric field refers to a kind of pulse electric field whose pulse width is at the nanosecond level, this kind of electric field can produce reversible electroporation [1] and irreversible electroporation (IRE) [2] on the cell membrane
Reversible electroporation is a transient hydrophilic hole in the cell membrane induced by the pulsed electric field [3]
Zim-mermann et al found that 1-10 kv/m pulse electric field can break through the red cell membrane, form a dielectric breakdown of the cell membrane, releasing hemoglobin, and the hemolytic mechanism causes cellular mechanical rupture or thermal rupture
Summary
The rabbitNanosecond pulse electric field refers to a kind of pulse electric field whose pulse width is at the nanosecond level, this kind of electric field can produce reversible electroporation [1] and irreversible electroporation (IRE) [2] on the cell membrane. The biophysical mechanism of non-thermal irreversible electroporation of pulsed electric field was studied. IRE treatment of pig pancreatic tissue is safe and effective.
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