Cancer targeted biomimetic drug delivery system

Abstract

Till now, cancer is one of the most serious diseases causing a high death ratio and a huge challenge to human health. Nanocarriers with the advantages of improved bioavailability and targeting property are one of the safe and effective approaches for cancer treatment. However, the traditional nanocarriers still face various challenges in clinical applications, such as strong cytotoxicity, easy to be recognized and removed by the immune system, and poor ability to penetrate cell membranes in the tumor tissue. In recent years, the biomimetic drug delivery systems (BDDS) have emerged as the new generation of carriers and drawn extensive attention due to their excellent biocompatibility, lower immunogenicity and easy to mimic the bio-structure and function of the biological system, which has become a promising drug delivery system and made significant progress for cancer targeting. This review summarizes the most up-to-date advances in biomimetic drug delivery systems for cancer targeting.