Abstract

Abstract Cancer stem cells have created great excitement in the research community. The concept that tumours are maintained by their own stem cells has revolutionized cancer research since the 70's. At this decade mutation in oncogenes and tumour suppressor genes were found to cause most human cancers. This led to formulating a clonal evolution concept, stating "it is proposed that most neoplasms arise from a single cell of origin, and tumour progression results from a quiet genetic viability within the original clone, allowing sequential selection of a more aggressive sub-line" [1]. This article is protected by copyright. All rights reserved.

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