Abstract
Thin slab PAGE was used to analyze 588 normal serum samples, 134 lung cancer samples and 68 noncancer lung diseases samples to determine whether distinct protein bands could be classified as tumor markers. Three distinct bands were noted. The band most frequently seen in the sera of lung cancer patients was of the molecular weight of 175, 000 Doltons while a band of 115,000 Doltons appeared with the sera of normal and noncancerous lung disease patients. These bands were termed “tumor positive” and “tumor negative” markers respectively. The tumor negative marker protein reacted readily with anti-C3, and it was called complement-related protein or Rc3. The tumor positive marker corresponded to lung cancer in 78.4% of cases; the false positive rates for normal and non-cancer lung diseases were 6% and 11%, respectively. The sensitivity of this method was 78.4% (S=78%); specificity was 86% (F=86%.)
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
