Abstract
SCreening lest is Iimited to asymptomatic individuals and its purpose is to decrease mortality. Beyond the technical issues involved in study design, other requirements addressing implementation,analysis,and interpretation including biases, must be met to demonstrate that a screening test is useful. A positive screening test may lead to early intervention that could allow "cure'' of the disease but not be efficacious for a person's general health. There are effective screening modalities for breast cancer ‘colorectal cancers , and cervical cancers,whereas no compelling evidence exists for the value to screening for lung cancer. Over the past few years ‘there have been rapid developments applying new imaging and molecular diagnostic modalities for the purpose of cancer screenings. Appropriate methods for incorporating these new techniques into screening trials must be considered.
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