Abstract
ABSTRACTThe accumulation of mutations and single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) is related to gastric carcinogenesis. To evaluate the potential relationships between DNA damage and D-loop SNPs, we measured the 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels in the gastric cancer tissue by immmunostaining. Our data showed that the gastric cancer susceptibility SNP of 16519C was associated with higher 8-OHdG levels. Taken together, the cancer-risk associated D-loop SNPs might initiate carcinogenesis through increasing oxidative damage.
Highlights
Gastric cancer is one of the most common malignancies and third leading cause of cancer-related mortality worldwide [1]
Further analysis showed that the 8-OHdG levels were associated with neither the clinical characteristics, nor the outcome of gastric cancer (Table 2)
Mutations and polymorphisms in the displacement loop (D-loop) have been associated with a number of cancers; ; only a few SNPs have been considered for prediction of cancer risk and outcome, and that with a still subtle predictive value [11,15,16]
Summary
Gastric cancer is one of the most common malignancies and third leading cause of cancer-related mortality worldwide [1] Both environmental factors and genetic factors contribute to the etiology of this multi-factorial disease, and the prognosis of gastric cancer remains poor due to the delayed diagnosis [2]. Earlier studies suggested that a number of cancer tissues, including lung cancer, breast cancer, hepatocellular carcinoma and gastric cancer, displayed higher 8-OHdG levels compared to nontumour tissues, but the functional significance of persistent oxidative stress in cancer tissues remain unknown [3,8,9,10]. We analysed the 8-OHdG levels in gastric cancer tissues to evaluate the relationships between these SNPs and the oxidative DNA damage
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