Abstract
Simple SummaryCancer is the second leading cause of death worldwide and incidence rates for several tumor entities are rising. Many patients develop additional comorbidities after cancer diagnosis. Among these, several psychological morbidities have been extensively studied in the past, but findings on the association between cancer and dementia have remained conflicting. We showed that the overall cumulative incidence of dementia was significantly higher in cancer patients than in non-cancer patients, which should raise awareness of this important comorbidity in cancer patients.Background: Cancer is the second leading cause of death worldwide and incidence rates for several tumor entities are rising. In addition to a high cancer-specific mortality rate, many cancer patients also suffer from additional comorbidities. Among these, several psychological morbidities have been extensively studied in the past, but findings on the association between cancer and dementia have remained conflicting. In the present study, we evaluated the possibility of an association between cancer and dementia. Methods: Based on data from the IQVIA Disease Analyzer database, a total of 92,868 cancer outpatients initially diagnosed between 2000 and 2018 were matched by age, gender, index year, and yearly consultation frequency to 92,868 individuals without cancer. Ten-year incidence rates of dementia were compared for the two cohorts. Results: The overall cumulative incidence of dementia was significantly higher in cancer patients (19.7%) than in non-cancer patients (16.7%, p < 0.001). Cox regression models confirmed that this association was significant for both male (HR: 1.35 [1.30–1.41], p < 0.001) and female (HR: 1.26 [1.21–1.31], p < 0.001) patients and was consistent among all age groups analyzed (65–70, 71–75, 76–80, 81–85, and >85 years). In addition, the association between cancer and dementia was significant for all cancer entities analyzed (skin, digestive organs, prostate, breast, urinary tract, lymphoid and hematopoietic tissue, and lung cancer) and most pronounced in patients with lung cancer (HR: 1.44 [1.28–1.62], p < 0.001). Conclusions: Our data provide strong evidence for an increased incidence of dementia in a large cohort of patients with different cancer entities, which should raise awareness of this important comorbidity in cancer patients.
Highlights
With increasing life expectancy, both the incidence and prevalence of age-related diseases such as cancer and dementia have risen dramatically
As cancer and dementia affect a similar collective of patients, numerous analyses in the past have addressed the possibility of a causal relationship between the two diseases and investigated whether cancer may be causal for dementia, and whether dementia can lead to cancer
To investigate a potential association between cancer and dementia, we identified a total of 92,868 cancer patients who were matched to a cohort of equal size without cancer
Summary
Both the incidence and prevalence of age-related diseases such as cancer and dementia have risen dramatically. The association between cancer and cognitive impairment has been analyzed in multiple population-based studies. Other analyses reported that these inverse correlations between cancer and dementia might be restricted to specific etiologies such as Alzheimer’s disease and diminish over time, arguing that the association between cancer and general risk of dementia is limited [12]. Cancer is the second leading cause of death worldwide and incidence rates for several tumor entities are rising. Methods: Based on data from the IQVIA Disease Analyzer database, a total of 92,868 cancer outpatients initially diagnosed between 2000 and 2018 were matched by age, gender, index year, and yearly consultation frequency to 92,868 individuals without cancer. Conclusions: Our data provide strong evidence for an increased incidence of dementia in a large cohort of patients with different cancer entities, which should raise awareness of this important comorbidity in cancer patients
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
