Abstract
Cancer of the thyroid gland occurs in many different clinical and histologic forms, and its variations have resulted in the use of a widely varying nomenclature. In 1928 Clute and Smith (1) attempted to correlate the histologic findings in thyroid malignancy with the clinical course of the disease. At that time Dr. Lawrence Smith, working with material then available, suggested the following histologic grouping: (1) malignant adenomas, including papillary adenoma and the fetal adenoma; (2) squamous-cell carcinoma; (3) giant-cell carcinoma; (4) small-cell carcinoma. He found that, although there were minor variations in the histologic picture in any one group, there was a marked uniformity in the ultimate clinical course of the cases in the group.
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