Abstract
The aim of the present study was to estimate total cancer mortality trends from 1982 to 2011 in a “low rate of land use” province of the Latium region (Rieti, central Italy) characterized by a low degree of urbanization, a high prevalence of elderly, and a low number of births. Mortality data of the studied period, provided by the Italian National Institute of Statistics, were used for calculating standardized cancer mortality rates. Trends in mortality were analyzed using Joinpoint regression analysis. Results showed that total standardized cancer mortality rates decreased in the monitored area over the study period. A comparison with other provinces of the same region evidenced that the studied province presented the lowest cancer mortality. The three systems/apparatuses affected by cancer that mainly influenced cancer mortality in the monitored province were the trachea-bronchus-lung, colorectal-anus, and stomach. These findings could be attributed to the implement of preventive initiatives performed in the early 2000s, to healthier environmental scenario, and to lower levels of carcinogenic pollutants in air, water, and soil matrices. Thus, our results indicate that the studied area could be considered a “healthy” benchmark for studies in oncological diseases.
Highlights
Cancer remains one of the most common causes of death worldwide
The program can be used for assessing andCancer
In many countries, including Italy, there are no routine surveillance programs and no benchmark areas have been established to carry out appropriate comparisons; this gap can be partially filled by ad hoc studies describing epidemiological profiles of cancer in specific areas
Summary
Cancer remains one of the most common causes of death worldwide. a recent systematic analysis for the global burden of diseases highlighted that cancer was the second leading cause of death.Globally, it is estimated that there were 18.1 million new cancer cases and 9.6 million cancer deaths in2018 [1]. Cancer remains one of the most common causes of death worldwide. A recent systematic analysis for the global burden of diseases highlighted that cancer was the second leading cause of death. It is estimated that there were 18.1 million new cancer cases and 9.6 million cancer deaths in. In Italy, the number of deaths attributed to cancer in 2014 was 177,301 and, likewise in other developed countries, cancer was the second cause of death (29% of all deaths) after cardiovascular diseases (37%) [2]. In Italy, in 2017, over 369,000 new cases of cancer were diagnosed Aging seems to be a key factor in the development
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