Abstract
Cancer metabolism of cone photoreceptors.
Highlights
Cancer cells divert cellular physiology for their own growth through activation of proto-oncogenes and inactivation of tumor suppressors by somatic mutations, amplifications, translocations and loss of alleles
The conformational change requires that opsin is embedded in a lipid bilayer of optimal fluidity, fluidity that comes from its lipid composition enriched in polyunsaturated fatty acids
We developed a therapeutic strategy aimed at preventing vision loss in patients suffering from retinitis pigmentosa, the most common form of inherited retinal degeneration
Summary
Cancer cells divert cellular physiology for their own growth through activation of proto-oncogenes and inactivation of tumor suppressors by somatic mutations, amplifications, translocations and loss of alleles. Rods are very sensitive to light and are saturated in daylight, while cones are responsible of color vision and all visual performance during the day. Oxidized lipids are removed daily through phagocytosis by the retinal pigmented epithelium.
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