Cancer mamar apărut în timpul tratamentului cu inhibitori PARP pentru un cancer ovarian cu mutaţie BRCA somatică – prezentare de caz

Abstract

Breast and ovarian cancer are relatively frequent malig­nan­cies in BRCA mutation carrier patients. The synchronous pre­sence of these two cancers is a challenging clinical situation, es­pe­cial­ly in young women. We present a case report of a young woman diagnosed with high-grade serous ovarian car­ci­no­ma, somatic BRCA-mutant, who developed breast cancer during PARP inhibitor treatment. The right treatment choice for both malignancies may be equally thought-provoking for patient and doctor in face of recurrence risk reduction end­point. This case report emphasizes real life progression-free survival on PARP inhibitor treatment higher than in phase III clinical trials.