Cancer incidence in patients with type 2 diabetes mellitus: a population-based cohort study in Shanghai.

Hui-Lin Xu,Yu-Jie Yan,Fen Zhang,Guo-You Qin,Wei-Xi Li,Yi-Nan Liu,Yan-Ping Zhao,Jin-Ling Zhang,Hong Fang,Nai-Qing Zhao,Li-Yun Zhao,Wang-Hong Xu,Lun-Qiang Li,Na Wang,Bao-Dong Yao,Jie Zhou

doi:10.1186/s12885-015-1887-4

Hui-Lin Xu, Yu-Jie Yan + Show 14 more

Open Access

https://doi.org/10.1186/s12885-015-1887-4

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Abstract

BackgroundType 2 diabetes mellitus (T2DM) has been suggested to increase the risk of cancers. The aim of this study was to investigate the risk of common cancers in Chinese patients with T2DM.MethodsA population-based retrospective cohort study including 36,379 T2DM patients was conducted in Minhang District of Shanghai, China, during 2004 to 2010. All T2DM patients were enrolled from the standardized management system based on local electronic information system. Newly-diagnosed cancer cases were identified by record-linkage with the Shanghai Cancer Registry. Standardized incidence ratios (SIR) and 95 % confidence interval (CI) were used to estimate the risk of cancers among T2DM patients.ResultsOverall crude incidence rate (CIR) of cancers was 955.21 per 105 person-years in men and 829.57 per 105 person-years in women. Increased risk of cancer was found in both gender, with an SIR being 1.28 (95 % CI = 1.17–1.38) in men and 1.44 (95 % CI =1.32–1.55) in women. Increased risk of colon (SIR = 1.97; 95 % CI = 1.49 to 2.46), rectum (1.72; 1.23 to 2.21), prostate (2.87; 2.19 to 3.56), and bladder cancers (1.98, 1.28 to 2.68) were observed in men and elevated risk of colon (1.67; 1.25 to 2.08), breast (1.66; 1.38 to 1.95), and corpus uteri cancers (2.87; 2.03 to 3.71) were observed in women.ConclusionsOur results indicate that Chinese patients with T2DM may have an increased risk of some cancers, and the increase may vary by sub-sites of cancers.

Highlights

Type 2 diabetes mellitus (T2DM) has been suggested to increase the risk of cancers
To elucidate the associations of T2DM with the risk of cancers is important in China, because, with the huge population and high prevalence of T2DM, even a small increase in the cancer risk might have a significant public health impact at the population level for the country
The patients enrolled in the management system included: 1) part of prevalent T2DM patients; 2) newlydiagnosed T2DM patients from local comprehensive hospitals, 3) newly-diagnosed T2DM patients from regular health check-up programs for all local residents over 60 years provided by community health service centers (CHSC), and 4) newly-diagnosed T2DM patients from free screening for high risk group with specific symptoms or claims provided by CHSC

Summary

Introduction

Type 2 diabetes mellitus (T2DM) has been suggested to increase the risk of cancers. The aim of this study was to investigate the risk of common cancers in Chinese patients with T2DM. Type 2 diabetes mellitus (T2DM) is one of the major public health problems around the world. Epidemiologic evidence is accumulating on the association between T2DM and cancers, for cancers of colorectum [3,4,5], liver [6, 7], breast [8, 9], bladder [10], kidney [11], and prostate [12]. To elucidate the associations of T2DM with the risk of cancers is important in China, because, with the huge population and high prevalence of T2DM, even a small increase in the cancer risk might have a significant public health impact at the population level for the country

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