Abstract
BackgroundThe effectiveness of dialysis on the incidence of cancer in patients with end-stage renal disease (ESRD) remains to be clarified. In this study, we evaluated the incidence rate and type of cancer among patients with ESRD, compared to the general population, through a prospective 7-year follow-up. We also calculated the cumulative incidence rate of cancer associated with ESRD, with stratification to control for the competing risk of death.MethodsThis prospective observational cohort study was conducted using data from a nationwide study on patients with ESRD in Korea. A total of 5,235 patients, ≥18 years old, with ESRD were identified from the national registry as being treated by dialysis between August 2008 and December 2014. The standardized incidence ratio (SIR) and cumulative incidence rate of specific cancers were evaluated and compared to the general population.ResultsA total of 5,235 participants were included. During the 7 year observation period, 116 (2.2%) participants had been diagnosed as cancer. The SIR of overall cancer was 0.94 [95% confidence interval (CI), 0.72–1.19] and was comparable to the rate for the general population. Although the digestive organs were the most frequent site of a primary site cancer (N = 39, 33.6%), the SIR was highest for urinary tract cancer [4.7, 95% CI, 2.42–8.19]. The five year standardized cumulative incidence of cancer was higher for females than for males, and for non-diabetic compared to diabetic causes of ESRD. We estimated that the five year standardized cumulative incidence was highest [8.4, 95% CI, 5.07–13.75] in patients with ESRD, caused by glomerulonephritis.ConclusionA screening program should be necessary for urinary tract cancer in Korean patients with ESRD. Cancer screening programs for patients with ESRD in Korea should be emphasized on female patients and patients with non-diabetic ESRD.
Highlights
The incidence of malignant tumors is increasing worldwide
The digestive organs were the most frequent site of a primary site cancer (N = 39, 33.6%), the standardized incidence ratio (SIR) was highest for urinary tract cancer [4.7, 95% confidence interval (CI), 2.42–8.19]
The five year standardized cumulative incidence of cancer was higher for females than for males, and for non-diabetic compared to diabetic causes of end-stage renal disease (ESRD)
Summary
The incidence of malignant tumors is increasing worldwide. in patients with endstage renal disease (ESRD), cancer is the third leading cause of death, after cardiovascular disease and infection [1,2]. Several studies have reported a higher incidence rate of cancer among patient with ESRD than among the general population [3,4,5,6,7,8]. The aim of our study was to evaluate the incidence rate and type of cancer among patients with ESRD, compared to the general population, over a 7-year follow-up period. We evaluated the incidence rate and type of cancer among patients with ESRD, compared to the general population, through a prospective 7-year follow-up. We calculated the cumulative incidence rate of cancer associated with ESRD, with stratification to control for the competing risk of death
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
