Cancer Genomic Profiling of Gynecological Malignancies by Todai OncoPanel, a Twin DNA and RNA Panel

Abstract

Todai OncoPanel (TOP) has been established at The University of Tokyo and consists of DNA (version 3: 464 genes) and RNA panels (version 4: 463 genes). The University of Tokyo Hospital started TOP analysis in February 2017 as a research project approximately in 250 patients. Then, clinical sequencing for advanced solid tumors by TOP panel was performed as Advanced Medical Care Category B in 200 patients toward approval from the Ministry of Health, Labor and Welfare (Patient accrual was completed in December 2019). In this study, we performed TOP analysis in 54 gynecological malignancies and found various types of actionable somatic mutations, gene fusions, germline mutations (in BRCA1, BRCA2, and mismatch repair genes), as well as high tumor mutational burden. We describe the efficacy and the utility of TOP for gynecological malignancies, using our comprehensive analysis of the 54 gynecological malignancy cases. These findings will highlight the usefulness of cancer genomic profiling and shed light on precision medicine in gynecological malignancies.KeywordsCancer genomic profilingGynecological malignanciesPrecision medicineTodai OncoPanelTwin DNA and RNA panel