Cancer Diagnosis: A Universal Upconversion Sensing Platform for the Sensitive Detection of Tumour‐Related ncRNA through an Exo III‐Assisted Cycling Amplification Strategy (Small 10/2018)

Abstract

In article number 1703858, Xingcai Wu, Jun-Jie Zhu, and co-workers report a universal and sensitive upconversion sensing nanoplatform for detecting tumor-related non-coding RNA. The sensitivity of the probe is improved by tuning the number of DNA units on the gold nanoparticles, and an exonuclease III-assisted target cycling amplification strategy improves the sensitivity and achieves the universality of this sensing nanoplatform. Through this method, the expression level of microRNA-21 in human breast cancer cell lysate is successfully measured, suggesting its potential in cancer diagnosis.