Abstract
Cancer research in pursuit of better diagnostic and treatment modalities has seen great advances in recent years. However, the incidence rate of cancer is still very high. Almost 40% of women and men are diagnosed with cancer during their lifetime. Such high incidence has not only resulted in high mortality but also severely compromised patient lifestyles, and added a great socioeconomic burden. In view of this, chemoprevention has gained wide attention as a method to reduce cancer incidence and its relapse after treatment. Among various stems of chemoprevention research, nanotechnology-based chemoprevention approaches have established their potential to offer better efficacy and safety. This review summarizes recent advances in nanotechnology-based chemoprevention strategies for various cancers with emphasis on lung and bronchial cancer, colorectal, pancreatic, and breast cancer and highlights the unmet needs in this developing field towards successful clinical translation.
Highlights
Cancer poses a severe socioeconomic impact all over the world
As per the American Cancer Society, over 1,762,450 new cancer cases and about 606,880 cancer related deaths are estimated in the United States alone in 2019 (American Cancer Society, 2019a)
Late/limited diagnostic opportunities, faster progression, limited treatment options with severe toxicities, and frequent relapse are the key reasons for high cancer fatality and is an alarming concern despite extensive research conducted in this field and available clinical treatments far
Summary
Cancer poses a severe socioeconomic impact all over the world. As per the American Cancer Society, over 1,762,450 new cancer cases and about 606,880 cancer related deaths are estimated in the United States alone in 2019 (average of 4,830 new cases and 1,660 deaths per day) (American Cancer Society, 2019a). Enhancing the bioavailability of drug is a potential approach and various NPs like lipid, polymer, liposomes have been reported to do so.
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