Abstract
Purpose: Different compositions of copper oxide (CuO)-doped calcium silicate clusters were used to treat the cancer cells. Methods: The influence of CuO content on the morphology, drug delivering ability, physicochemical properties and cytotoxicity was investigated. Results: The microcrystalline structure revealed the decrement of the size from (20-36 nm) to (5-7 nm) depending on the copper content percentages. Drug delivering ability of doxycycline hyclate (Dox) was down regulated from 58% to 28%in the presence of the CuO. The inclusion of CuO and Dox didn’t show any remarkable changes on the physicochemical properties of the CuO-doped calcium silicate nanoparticles. Conclusion: The CuO-doped calcium silicate sample (5 weight %) exhibited great cytotoxicity against the tested cell lines compared to the CuO-free sample. CuO-doped materials displayed significant anticancer effect; this sheds light on its implication in the treatment of cancer.
Highlights
One of the major challenges that face researchers targeting the cancer treatment was the direct delivering of the lethal dose only to cancer cells without killing the normal cells
The compositions of CuO doped calcium silicate clusters might occur during the implantation operation, due to were synthesized as illustrated in the schematic diagram its chemotherapeutic effects.[8,9]
Nanoparticles calcium silicate powder doped with copper ions was prepared using wet precipitation method
Summary
One of the major challenges that face researchers targeting the cancer treatment was the direct delivering of the lethal dose only to cancer cells without killing the normal cells. To meet this challenge, biomedical researchers were looking for reliable local anticancer implants. Preparation method had important role in controlling the properties of nanoparticles, including the particle size, morphology and chemical composition. These properties believed to be well controlled by controlling the wet precipitation method parameters such as precursor’s ratios, reaction temperature, additives sequence and the reaction time. All these parameters could be adjusted in the wet precipitation method in order to tolerate the aforementioned nanoparticles properties as confirmed by previous studies.[3,4] In addition to that, low price precursors were used in the wet precipitation method compared to the sol-gel one
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