Abstract
Nucleus reflects a cell’s biological potential and activity. Nuclei of normal healthy cells are usually single per cell in number, round to oval shaped, show even distribution of chromatin, display regular nuclear margin or membrane, one or two inconspicuous nucleoli and normal mitotic figures. During development of cancer, the nucleus undergoes numerous alterations of size, shape, number, nuclear membrane or margin, chromatin pattern, nucleoli, and organization of nuclear chromatin.
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