Canadian province-level risk factor analysis of macrolide consumption patterns (2000-2006)

Abstract

To assess provincial-level predictors among socioeconomic and influenza rate data for the use of different macrolide antimicrobials in Canada from 2000 to 2006. Multivariable models were developed to describe macrolide defined daily doses per capita. Use was highest during October to March for all macrolides. Investigated yearly and provincial patterns differed considerably among the macrolide agents. Associations with socioeconomic variables were similar between clarithromycin and erythromycin, while azithromycin consumption showed some differences in its association with these variables. Consistently, the rate of influenza was significantly associated with increased macrolide use. The influenza rate interacted with socioeconomic variables in some models; as the influenza rate increased, the greatest increase in demand for macrolides occurred in populations with high percentages of low-income individuals, high unemployment levels and low percentages of individuals with bachelor's degrees. The impact of associations among macrolide consumption, influenza and socioeconomic factors may reflect inappropriate use of these agents to treat viral infections and/or prescribing for secondary infections, and knowledge of the virus versus bacteria problem and accessibility of healthcare. Further research surrounding differences in access to antimicrobial prescriptions and treatment options between advantaged and disadvantaged populations is suggested to further understand the dynamics of antimicrobial use in Canada.