Can we improve the results and increase the number of renal transplants?

Abstract

The two main aims of the transplant community are failure if antibodies exceeded 50%. In hyperimmunized to improve the results of organ transplantation and to patients, the HLA compatibility strongly influences the increase the number of donors. Here we will consider results. The pre-transplant removal of pre-formed antifirst the main factors that can influence the results of bodies with immunoadsorptive columns or plasma renal transplantation and then the possible measures exchanges may improve the results in patients with an to counteract the shortage of donors. elevated titre of circulating antibodies [5]. Factors influencing the results of renal Primary disease transplantation Idiopathic glomerulonephritis (GN ) may recur after transplantation and can lead to graft failure. The risk There is a long list of factors that may aVect the is particularly elevated for childhood focal glomerulooutcome of kidney transplantation. We will discuss, sclerosis which is responsible for graft failure in 24% however, only the most important variables. of cases. Mesangiocapillary GN type II is responsible of graft failure in 19% of cases, while the other GNs Centre eVect account for 4% of graft failures. With the exception of focal glomerulosclerosis that destroys the kidney within A retrospective investigation of >27 000 cadaveric