Abstract
COVID-19 has become an international pandemic and is causing a worldwide public health emergency; therefore, an effective treatment is urgently needed. The hypothesis is that Covid virus interferes with the cobalamin metabolism, causing symptoms of cobalamin deficiency. This is plausible to infer, because there are symptoms of vitamin B12 deficiency that are similar to those of COVID-19. These symptoms include increase oxidative stress, homocysteine concentration, activation of the coagulation cascade, thrombocytopenia, elevated lactate dehydrogenase (LDH), low reticulocyte count, intravascular coagulation thrombosis, vasoconstriction, renal and pulmonary vasculopathies, which can result in respiratory, gastrointestinal and central nervous system disorders. Research shows that high doses of methylcobalamin is the treatment for symptoms of vitamin B12 deficiency. Thus, an additional hypothesis is that treatment with vitamin B12, especially methylcobalamin, would reduce Covid's damage to infected patients. Hence, in this review article it is suggested that methylcobalamin (vitamin B12) may serve as an attenuator to COVID-19 symptoms. Clinical studies are required to confirm this hypothesis.
Highlights
COVID-19 is highly transmissible in humans; mostly presented with mild flu-like symptoms, but some patients, especially the elderly and people with underlying diseases, evolve critical condition and rapidly develop acute respiratory distress syndrome, respiratory failure, multiple organ disorder and death [1, 2]
There are more than 7.000.000 confirmed cases of Coronavirus disease-2019 (COVID-19 / SARS-CoV-2), with more than 400.000 deaths, in 188 countries/regions [Coronavirus Johns Hopkins, https://coronavirus.jhu.edu/, Last accessed on 11/06/2020]
In this review article I suggests that methylcobalamin form of vitamin B12 may serve as an attenuator of COVID19 symptoms
Summary
COVID-19 is highly transmissible in humans; mostly presented with mild flu-like symptoms, but some patients, especially the elderly and people with underlying diseases, evolve critical condition and rapidly develop acute respiratory distress syndrome, respiratory failure, multiple organ disorder and death [1, 2]. Highest cobalamin deficit may occur in the elderly, who have difficulty in absorbing this vitamin from food, due to the lack of gastric acid or the intrinsic factor needed to active absorption of B12 [5,6,7,8] This condition could be a likely explanation to the high vulnerability of the elderly to COVID-19 infection [1,2]. After a long and tiring search, I started vitamin B12 therapy, with cyanocobalamin injections, until I started to use sublingual methylcobalamin, with excellent clinical results Since this treatment, as I am a scientist and researcher in the biological field, I started to research scientific articles on vitamin B12. In this review article I suggests that methylcobalamin form of vitamin B12 may serve as an attenuator of COVID19 symptoms
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
