Abstract
AbstractThe interconnection between vision and somatosensation is already well-established and is further supplemented by the evolutionary link between eyes and photoreceptors, and the functional connection between photosensation and thermoreception. However, our analysis hypothesizes a possibility that vision is not just linked to somatosensation, but may not exist without somatosensation. Surprisingly, our photoreceptor itself needs somatosensory proteins for its functioning, and our entire visual pathway depends on somatosensory cues for its functioning.
Highlights
The interconnection between vision and somatosensation is already well-established and is further supplemented by the evolutionary link between eyes and photoreceptors, and the functional connection between photosensation and thermoreception
It is believed that peripheral stimuli are detected with the help of receptors, transduced into action potentials and conveyed to the central nervous system (CNS), recent studies suggest that even non-neuronal cells could be directly involved in somatosensation[15]
There has been a flurry of research about molecules, enzymes, proteins, lipids involved in somatosensation
Summary
Mechanical stretch, biophysical cues such as cell-cell and cell-matrix interactions control transcription and cause splicing of several mRNAs, and thereby, alter signal transduction, the expression of numerous genes, proteins and matrix metallo proteases (MMPs), remodel and change the composition of the HTM extra-cellular matrix(ECM). These factors in turn modulate the aqueous humour outflow causing glaucoma[9,12,28]. The rodent retina has been found to harbour the MS epithelial sodium channels (ENaC), their role in photoreception remains to be proved-57
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