Abstract
Can UPR integrate fasting and stem cell regeneration?
Highlights
Edited by: Maria Cecilia Giron, University of Padova, Italy Reviewed by: Matiullah Khan, AIMST University, Malaysia
While prolonged fasting may not be an attractive and practical option for the debilitated and the elderly, further research into the phenomenon can lead to the discovery of molecular targets which can mimic the similar effect without food deprivation
An alternate view of this observation revolves around this question: what is the state of cellular stress under fasting? During glucose starvation, a condition analogous to fasting, the cells undergo stress, and cellular stresses collectively give rise to unfolded protein response (UPR) in the endoplasmic reticulum (ER) and, subsequently, ER stress
Summary
Edited by: Maria Cecilia Giron, University of Padova, Italy Reviewed by: Matiullah Khan, AIMST University, Malaysia. A commentary on Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression by Cheng, C. In order to find ways to counter massive loss of regeneration and self-renewal that the stem cells (SCs) suffer from following chemotherapy, the cancer biologists have set foot in regenerative medicine.
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