Abstract
ABSTRACT: Progressive deterioration and loss of articular cartilage are the final degenerative events common to osteoarthritis (OA). Reactive oxygen species (ROS) play an important role in this chondrocyte catabolic activity, leading to cell death and matrix components breakdown. Intra-articular corticosteroid injections such as triamcinolone acetonide have been used to control pain and inflammation associated with OA. New treatments for OA, platelet-rich plasma and pentosan polysulphate sodium have also been used and further investigations are necessary to determine their safety in joint cells. In this in vitro study, the use of these three substances (triamcinolone acetonide, platelet-rich plasma, and pentosan polysulphate sodium) in healthy chondrocytes did not alter the antioxidant status when compared to control groups, indicating that they could be considered safe in healthy conditions.
Highlights
Hyaline cartilage provides a low-friction gliding surface, with increased compressive strength and it is known to be wear-resistant under normal circumstances
It consists of chondrocytes and a dense extracellular matrix composed primarily of water, collagen, and proteoglycan
Fragments were placed in a Petri dish containing DMEM (Dulbecco Modified Eagle’s Medium) culture medium supplemented with 10% fetal bovine serum (FBS), 60 U/mL penicillin, 60 μg/mL streptomycin and 2 mmol/L glutamine
Summary
Hyaline cartilage provides a low-friction gliding surface, with increased compressive strength and it is known to be wear-resistant under normal circumstances. It consists of chondrocytes and a dense extracellular matrix composed primarily of water, collagen, and proteoglycan. Articular cartilage is a highly-specialized tissue with poor regenerative capacities, because of its low metabolic activity. In this way, the balance between anabolism and catabolism of the matrix is crucial for this tissue homeostasis (BHOSALE & RICHARDSON, 2008; PEARLE et al, 2005). At some point the biosynthetic anabolic activity is unable to keep the pace with the degradative catabolic activity, and degeneration of the tissue results, leading to the occurrence of diseases such as osteoarthritis (OA) (SANDELL & AIGNER, 2001)
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