Abstract
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Highlights
glucose-6-phosphate dehydrogenase deficient (G6PDd)-red blood cells (RBCs) therapeutically-rational exchange (T-REX) may prove worthwhile since it involves removing the patient’s parasitized RBCs which can be lethal due to their cytoadherence and replacing them with malaria-protective G6PDd RBCs which are thought to inhibit the parasites via oxidative stress
G6PDd-RBC T-REX may prove worthwhile since it involves removing the patient’s parasitized RBCs which can be lethal due to their cytoadherence and replacing them with malaria-protective G6PDd RBCs which are thought to inhibit the parasites via oxidative stress
G6PDd-RBC units are prevalent in many blood banks; and many patients, with and without malaria, have already been transfused G6PDd RBCs
Summary
G6PDd-RBC T-REX may prove worthwhile since it involves removing the patient’s parasitized RBCs which can be lethal due to their cytoadherence and replacing them with malaria-protective G6PDd RBCs which are thought to inhibit the parasites via oxidative stress. J Nepal Health Res Counc 2018 Jan-Mar;16(38):[108] Can the Therapeutically-rational Exchange (T-REX) of Glucose-6-phosphate Dehydrogenase Deficient Red Blood Cells Reduce Plasmodium falciparum Malaria Morbidity and Mortality?
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