Can the Nonstress Test Predict Congenital Sepsis?

Abstract

The possible role of the nonstress test (NST) in the prediction of congenital sepsis in pregnancies complicated by prolonged premature rupture of the membranes (PROM) was investigated in a retrospective controlled study. Thirteen NSTs performed within 24 hours of the delivery of infants with congenital sepsis were coded, blinded, and mixed with an equal number of blinded NSTs derived from randomly selected patients matched for gestational age with PROM but without neonatal or maternal infection. Eleven of 13 infants with congenital sepsis had a reactive NST, and two had a nonreactive test. Among the controls, there were also 11 reactive and two nonreactive NSTs. The sensitivity and specificity of the NST in predicting congenital sepsis in patients with PROM were 15.4% and 84.6%, respectively. The positive predictive value and the negative predictive value were 50%. Our results suggest that the NST is not a useful tool for prediction of congenital sepsis.