Abstract
Background: The FUT2 gene (Se gene) encoding the enzyme α-1,2-L-fucosyltransferase 2 seems to have a significant effect on the number and type of bacteria colonizing the intestines. Methods: In a group of 19 patients after bariatric surgery, the polymorphism (rs601338) of FUT2 gene was analyzed in combination with body mass reduction, intestinal microbiome (16S RNA sequencing), and short chain fatty acids (SCFA) measurements in stools. Results: Among the secretors (Se/Se polymorphism of the FUT2 gene rs601338, carriers of GG variant), correlations between waist-hip ratio (WHR) and propionate content and an increase in Prevotella, Escherichia, Shigella, and Bacteroides were observed. On the other hand—in non-secretors (carriers of GA and AA variants)—higher abundance of Enterobacteriaceae, Ruminococcaceae, Enterobacteriaceae, Clostridiales was recorded. Conclusions: The increased concentrations of propionate observed among the GG variants of FUT 2 may be used as an additional source of energy for the patient and may have a higher risk of increasing the WHR than carriers of the other variants (GA and AA).
Highlights
The number of patients with severe obesity is gradually increasing
The study was attended by patients who were after bariatric surgery and had depressive disorders
Metagenome studies on obesity have obesity havethe shown that the intestinal of microbiome of anwas obese man was enriched withinvolved pathways shown that intestinal microbiome an obese man enriched with pathways in involved in microbiological processing of carbohydrates, as well microbiological processing of carbohydrates, as well as genes as genes involved the production of short chain fatty acids (SCFA)
Summary
The number of patients with severe obesity is gradually increasing. With relation to conservative treatments, bariatric surgery is considered to be a more effective way of treating patients with severe obesity, leading to reduction in both weight and coexisting diseases and mortality [1]. According to the American Society for Metabolic and Bariatric Surgery, the number of metabolic and bariatric procedures performed in 2018 was 10.8% higher than in 2017; only approximately 1% of all patients who qualify for bariatric surgery undergo surgery [2]. One of the factors that may be involved in the pathogenesis of severe obesity is intestinal microbiota. The mechanism includes changes in the composition of intestinal bacteria described as intestinal dysbiosis (disturbed relation between Bacteroidetes and Firmicutes types) generating inflammation [3]. 2 seems to have a significant effect on the number and type of bacteria colonizing the intestines
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