Abstract
Background: Breast cancer is regarded as the most common malignancy in females worldwide,it is representing 25% of all cancer cases diagnosed in women.The Oncotype DX recurrence score (RS) assay analyzes gene expression using a reverse transcriptase-polymerasechain reaction method,the tested panel includes 21 genes(16cancer-related genes and 5 reference genes).Its introduction resulted in significant changes in the adjuvant treatment decisions.It provides prognostic information for distant disease recurrence in with low burden axillary disease,ER +ve,HER2-ve early breast cancer that is independent of clinico-pathologic characteristics.
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