Abstract
We evaluated whether spike-rates are useful as an outcome parameter following vagus nerve stimulation (VNS). Spikes/minute and spikebursts/minute were counted in serial electroencephalograms before and after implantation of a vagus nerve stimulator in n=19 patients with severe childhood epilepsies. In the period of 2 years post VNS, spike-rate and reported seizure frequency were significantly correlated (Spearman’s R=0.61); spikebursts and seizures were correlated with R=0.74. The response rate, counted after 6 months, was too small to detect differences in responders and non-responders as to spike-reduction. Larger samples and effect sizes are necessary to prove the hypothesis that spike reduction is useful as outcome parameter after VNS or other interventions.
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