Abstract
Purpose: To evaluate the relationship between visual outcome and the photoreceptor inner segment/outer segment (IS/ OS) layer status in patients with macular edema of any etiology. Design: Cross-sectional study Patients with macular edema of any etiology and who did not present with a disrupted IS/OS line were enrolled. We obtained simultaneous visual acuity and optical coherence tomography (OCT) of patients with macular edema using a spectral-domain (SD) OCT system. The device recorded retinal thickness on tomography. SD OCT was recorded repeat- edly in patients before and after treatment with an anti-vascular endothelial growth factor agent or triamcinolone, and the central thickness, IS, and OS were measured. The IS/OS ratio was calculated, and the data were analyzed statistically. We also reviewed the OCT scans to determine the type of macular edema, i.e., cystoid macular edema or diffuse macular edema (absence of any cysts). Results: Forty-eight patients (48 eyes: 21 male and 27 female; median age, 58.50 ± 10.8 years) with macular edema were en- rolled. Twenty-seven eyes had cystoid macular edema, and 10 eyes had diffuse macular edema. The median central subfield thickness was 462 ± 150.3 μm. The IS/OS layer was observed in all 48 eyes, and the IS/OS ratio was calculated. Eight (16.7%), 11 (22.9%), and 29 (60.4%) eyes had venous tributary occlusion, post-cataract cystoid macular edema, and diabetic macular edema, respectively. There was a significant difference between pre- and post-treatment vision (p = 0.001, Table 2). When we compared the pre and post treatment IS, OS, and IS/OS ratio with t test (p = 0.000 with 95% CI). The presenting vision differed significantly according to the IS/OS ratio (p = 0.010, Table 3). Conclusion: This study demonstrated that the IS/OS ratio is not significantly correlated with final visual acuity following treatment for macular edema.
Highlights
Macular edema is a complication of many ocular conditions and currently affects an estimated 8% to 10% of the 23.6 million diabetics in the U.S [1] Because the prevalence of diabetes is expected to grow to more than 300 million cases worldwide by 2025,[2] the prevalence of macular edema is expected to increase substantially.The development of macular edema is initiated by hyper-permeability of the retinal vasculature, allowing extracellular fluid to accumulate in the retina
The inner segment/outer segment (IS/OS) layer was observed in all 48 eyes, and the IS/OS ratio was calculated
This study demonstrated that the IS/OS ratio is not significantly correlated with final visual acuity following treatment for macular edema
Summary
Macular edema is a complication of many ocular conditions and currently affects an estimated 8% to 10% of the 23.6 million diabetics in the U.S [1] Because the prevalence of diabetes is expected to grow to more than 300 million cases worldwide by 2025,[2] the prevalence of macular edema is expected to increase substantially.The development of macular edema is initiated by hyper-permeability of the retinal vasculature, allowing extracellular fluid to accumulate in the retina. Macular edema is a complication of many ocular conditions and currently affects an estimated 8% to 10% of the 23.6 million diabetics in the U.S [1] Because the prevalence of diabetes is expected to grow to more than 300 million cases worldwide by 2025,. [2] the prevalence of macular edema is expected to increase substantially. The development of macular edema is initiated by hyper-permeability of the retinal vasculature, allowing extracellular fluid to accumulate in the retina. Ischemic dysfunction of the neuroglia cells due to macular edema results in visual disturbance. Can spectral-domain optical coherence tomography findings forecast visual outcome in the case of macular edema?. Have been used to control macular edema. Complete resolution of the condition is not always possible, and a better understanding of the pathophysiology of macular edema is necessary
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