Can SCUBE1 be used to predict the early diagnosis, lesion volume and prognosis of acute ischemic stroke?

Hasan Ata Bolayir,Seyda Figul Gokce,Asli Bolayir,Serkan Kapancik,Burhanettin Cigdem,Aydin Gulunay,Veysel Kenan Celik,Özlem Kayim Yildiz

doi:10.1515/tjb-2018-0040

Hasan Ata Bolayir, Seyda Figul Gokce + Show 6 more

Open Access

https://doi.org/10.1515/tjb-2018-0040

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Abstract

Abstract Objective SCUBE1 [signal peptide-CUB (complement C1r/C1 s)-EGF (epidermal growth factor)-like domain-containing protein 1] is a novel biochemical marker. SCUBE1 is thought to play roles both in platelet activation and inflammation, which are important stages for the development of acute ischemic stroke (AIS).The purpose of our study was to determine the diagnostic and prognostic values and temporal change of plasma SCUBE1 levels in AIS patients. Materials and methods Thirty-five patients diagnosed with AIS at the Cumhuriyet University Faculty of Medicine Neurology Department, between June and December 2017, and a control group of 35 healthy volunteers were included. Results Median first day SCUBE1 value in the patient group was 97.51 ng/mL, and the median 7th day SCUBE1 value was 32.72 ng/mL. Median control group SCUBE1 value was 27.51 ng/mL. The first day SCUBE1 levels were significantly higher than the 7th day and the control group SCUBE1 levels (p=0.001, p<0.001, respectively). The ROC analysis showed that SCUBE1 levels above 68.8 ng/mL can be used as an indicator with high sensitivity and specificity for AIS diagnosis. Multivariate analysis revealed that the first day SCUBE1 had significant independent effects on development of AIS. In correlation analysis, plasma SCUBE1 levels showed a significantly positive correlation with lesion volume, NIHSS and MRS values (p<0.01). Conclusion First day plasma SCUBE1 values in AIS patients rised at significant levels compared to the control group. SCUBE1 could use both in the early diagnosis and prediction of prognosis and lesion volume of AIS patients.

Highlights

Stroke is a clinical syndrome that is characterized by quickly progressing signs of the focal loss of cerebral function, without evident reason except for the mentioned one of vascular origin, and the stroke symptoms must last for a period longer than 24 h or cause death [1]
This study is the first study in the literature which shows that there may be a positive linear correlation between the lesion volume and acute period SCUBE1 levels in human acute ischemic strokes (AIS) patients
It is revealed in our study that elevated plasma SCUBE1 levels could be associated with high National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scores (MRS) values in the acute phase of AIS

Summary

Introduction

Stroke is a clinical syndrome that is characterized by quickly progressing signs of the focal loss of cerebral function, without evident reason except for the mentioned one of vascular origin, and the stroke symptoms must last for a period longer than 24 h or cause death [1]. Acute ischemic strokes (AIS) make up 85% of all strokes [3]. The three most common etiologic factors of AIS are large vessel atherosclerosis, cardioembolic stroke and lacunar infarcts [1]. The inflammatory process represents a significant stage for developing atherosclerosis in the AIS pathogenesis [2]. It is known that platelet activation has a key role in the development of both cardioembolic stroke and large-vessel atherothrombotic stroke (LAT) [4, 5]. In studies carried out on experimental cerebral ischemia, an increase has been determined in the generation of a number of molecules, such as vascular cell adhesion molecules and various inflammatory markers [2, 3]

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