Abstract
Can Reverse T3 Assay Be Employed to Guide T4 vs. T4/T3 Therapy in Hypothyroidism?
Highlights
Reviewed by: Birte Nygaard, IT University of Copenhagen, Denmark Gabriela Brenta, Dr César Milstein Care Unit, Argentina
This article explores the potential use of reverse T3 for this role
Reverse T3 is generated from deiodination of T4 with production of ∼28 mcg/daily, but through deiodination of its inner ring by deiodinase type 3 (D3) (Figure 1)
Summary
Reviewed by: Birte Nygaard, IT University of Copenhagen, Denmark Gabriela Brenta, Dr César Milstein Care Unit, Argentina. The inactivation of T4 with generation of rT3 or T2 has a homeostatic role by protecting tissues from excess of thyroid hormones. Deiodination of the outer ring of T4 by D1 or D2 has been termed the activating pathway of T4 metabolism as it generates the most active thyroid hormone, T3.
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