Can QT dispersion predict multi-vessel coronary artery disease in patients with acute coronary syndrome?

Abstract

Objective. This study was planned to evaluate relation between QT dispersion (QTd) and multi-vessel coronary artery disease in acute coronary syndrome. Methods. This study included 225 consecutive patients with a diagnosis of non-ST segment elevation acute coronary syndrome. Three groups were defined as single vessel, two vessels, and three vessels. Echocardiographic, biochemical and electrocardiographic parameters of the three groups were compared. Results. QTd, corrected QT dispersion (QTcd) and corrected QT max values significantly increased in patients with three-vessel disease compared to the patients with single-vessel disease group (60±27 vs 45±28 ms, 68±32 vs 50±32 ms and 471±52 vs 443±48 ms; p =0.002, p = 0 .001 and p =0.001, respectively). In addition, QTd and QTcd were statistically more increased in patients with two-vessels disease than single-vessel disease group (57±29 vs 45±28 ms; p =0.045, and 63±32 vs 50±32 ms; p =0.046, respectively). Conclusion. In patient with acute coronary syndrome and diffuse vessel disease, changes in the myocardial cells due to ischemia cause more of the QT dispersion in the patients with multi-vessel disease than those with single-vessel disease.