Abstract
In an innovative study in the current issue of Biological Psychiatry, Fink et al. (1) examine electrophysiological features of induced pluripotent stem cell–derived neurons from patients with chromosome 15q11-q13 duplication (Dup 15q) syndrome with the goal of elucidating the mechanisms underlying neuronal hyperexcitability and seizure susceptibility in this neurogenetic syndrome. Their results reveal that Dup15q neurons do indeed show several features that may contribute to epileptogenesis. These features include but are not limited to increased excitatory synaptic events, reduced inhibitory synaptic transmission, increased frequency of spontaneous action potential firings, and disruption of potassium channels.
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