Abstract
ObjectiveTo assess the utility of metabolic parameters obtained from baseline and post-neoadjuvant chemotherapy (NAC) 18F FDG PET/CT scans in predicting postoperative residual cancer burden (RCB) scores in locally-advanced breast cancer (LABC). MethodsIn our retrospective study, we enrolled 58 LABC patients who underwent baseline and post-treatment 18F FDG PET/CT scans followed by surgery between June 2020 and February 2022. Patients were categorized by their molecular subtypes as Luminal groupe (Luminal A and Luminal B (HER 2 negative)), HER2 positive and triple-negative (TN). We recorded various metabolic parameters, including maximum standardized uptake value (SUVmax), mean SUV (SUVmean), metabolic tumor volume (MTV), total lesion glycolysis (TLG), maximum standardized uptake lean body mass (SULmax), and mean SUV lean body mass (SULmean) of the primary tumor (T). To minimize the effect of SUV changes between PET studies, SUV ratios of tumor and liver were recorded for each study as TLR1 and TLR2 respectively. We calculated the percent reduction in SUVmax (ΔSUVmax%) between 2 PET studies. Patients were categorized into two groups based on postoperative RCB scores: RCB0/I (pathological responders, pR) and RCB II/III (pathological non-responders, non-pR). ResultsTwenty-six patients (44.8%) were pR and 32 (55.2%) were non-pR. Baseline metabolic parameters were similar in 2 groups. Post-treatment T SUVmax2, T SUVmean2, T SULmax2, T SULmean2, TLR SUV2, and TLR SUL2 values were significantly different between the pR and non-pR patients across all molecular subgroups. Also, pR patients exhibited a significantly higher mean ΔSUVmax compared to non-pR patients. In the Luminal and HER2 positive groups, T SUVmax2 and T SUVmean2 values successfully discriminated the pR and non-pR groups with high accuracy, achieving 100% sensitivity and 100% specificity in the luminal group. In the luminal group, a −75.4% cut-off value for ΔSUVmax predicted pR with 100% sensitivity. ConclusionOur findings indicate that SUV parameters, normalized to lean body mass as recommended by PERCIST, can be valuable for the early non-invasive prediction of pR and non-pR patients using post-NAC 18F FDG PET/CT.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callSimilar Papers
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
