Abstract
BackgroundUniversally maximum standardized uptake value (SUVmax) and lactate dehydrogenase (LDH) are used as tools for response assessment in Hodgkin Lymphoma (HL) patients. Our objectives are to evaluate the predictive potential and response assessment of total lesion glycolysis (TLG) and metabolic tumor volume (MTV)—maximum three target lesions—as another alternatives and to investigate the correlation between TLG and MTV with LDH.ResultsBoth initial SUVmax and TLG were significantly associated with early patient response (p value 0.03, 0.047, respectively). An optimal threshold for SUVmax and TLG less than or equal 19.52, and 158.6, respectively, correlated with better therapeutic response. Initial LDH was moderately correlated with initial values of TLG (rs = 0.4, p value 0.01), MTV (rs = 0.44, p value 0.01) and SUVmax (rs = 0.42, p value 0.01).ConclusionTLG in correlation with LDH can be significant prognostic factors of therapeutic response in HL. They can be used for the identification of a subset of HL patients with a better outcome.
Highlights
Maximum standardized uptake value (SUVmax) and lactate dehydrogenase (LDH) are used as tools for response assessment in Hodgkin Lymphoma (HL) patients
We investigated the predictive value of both target lesions’ metabolic tumor volume (MTV) and total lesion glycolysis (TLG) instead of Whole-body metabolic tumor volume (WBMTV) and whole-body TLG (WBTLG) by using the new response evaluation criteria in lymphoma 2017 [6]
Patients with Complete response (CR) were found to significantly had lower levels of SUVmax and TLG compared to patients with Non-complete response (nCR) (p value 0.03, 0.047, respectively)
Summary
Maximum standardized uptake value (SUVmax) and lactate dehydrogenase (LDH) are used as tools for response assessment in Hodgkin Lymphoma (HL) patients. Our objectives are to evaluate the predictive potential and response assessment of total lesion glycolysis (TLG) and metabolic tumor volume (MTV)—maximum three target lesions—as another alternatives and to investigate the correlation between TLG and MTV with LDH. Functional studies with quantitative parameters play a great role in oncologic management. MTV (WBMTV) and whole-body TLG (WBTLG), with few available studies on target lesions’ MTV and TLG. We investigated the predictive value of both target lesions’ MTV and TLG instead of WBMTV and WBTLG (which are time consuming and need advanced software) by using the new response evaluation criteria in lymphoma 2017 [6]
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